Payseur Bret A, Cutter Asher D
Laboratory of Genetics, University of Wisconsin, Genetics/Biotechnology 2428, 425-G Henry Mall, Madison, WI 53706, USA.
Trends Genet. 2006 Aug;22(8):424-9. doi: 10.1016/j.tig.2006.06.009. Epub 2006 Jun 27.
Single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) differ in mutation rate and mechanism. As a result of these differences, simultaneous consideration of polymorphism patterns at SNPs and STRs can provide insights that are difficult to obtain from analysis of either marker type in isolation. Here, we use coalescent simulations to model the opposing effects of contrasting mutational dynamics and of shared genealogical history on the correlation between polymorphism at linked SNPs and STRs. Results show that polymorphism patterns are correlated only weakly despite the shared underlying genealogy, underscoring the importance of divergent mutational processes. Examples illustrate how knowledge of these relationships could aid population genetic inference, indicating the need for thorough theoretical studies.
单核苷酸多态性（SNPs）和短串联重复序列（STRs）在突变率和机制上存在差异。由于这些差异，同时考虑SNPs和STRs的多态性模式能够提供单独分析任何一种标记类型时难以获得的见解。在这里，我们使用合并模拟来建模对比突变动态和共享系谱历史对连锁SNPs和STRs多态性之间相关性的相反影响。结果表明，尽管存在共同的基础系谱，但多态性模式之间的相关性很弱，这突出了不同突变过程的重要性。实例说明了了解这些关系如何有助于群体遗传推断，表明需要进行深入的理论研究。
