Walder Deborah J, Andersson Terese L C, McMillan Amanda L, Breedlove S Marc, Walker Elaine F
Psychology Department at Brooklyn College-City University of New York, Brooklyn, NY 11210, USA.
Schizophr Res. 2006 Sep;86(1-3):118-22. doi: 10.1016/j.schres.2006.04.006. Epub 2006 Jun 27.
The 2nd to 4th finger digit ratio (2D:4D) is a sexually dimorphic feature determined during gestation indexing prenatal androgen/estrogen levels. More 'feminized' 2D:4D phenotype has been demonstrated in schizophrenia versus same-sex controls. This study examined 2D:4D in adolescents with schizotypal personality disorder (SPD). Among normal controls, right 2D:4D was significantly greater (more feminized) in females than males. We replicated laterality effects; significant sex differences only on right. There were no significant sex differences among SPDs. Diagnostic group differences were restricted to White/Caucasian males with greater right 2D:4D in SPDs. Findings suggest disruptions in prenatal gonadal hormones in vulnerability for schizophrenia.
第二至第四指比例（2D:4D）是一种在孕期确定的性二态特征，可指示产前雄激素/雌激素水平。与同性对照组相比，精神分裂症患者表现出更“女性化”的2D:4D表型。本研究调查了分裂型人格障碍（SPD）青少年的2D:4D。在正常对照组中，女性的右手2D:4D显著大于男性（更女性化）。我们重复了偏侧性效应；仅右手存在显著的性别差异。SPD患者之间不存在显著的性别差异。诊断组差异仅限于白人/高加索男性，SPD患者的右手2D:4D更大。研究结果表明，产前性腺激素紊乱与精神分裂症易感性有关。
