高危青少年的神经认知与向精神病的转变
Neurocognition and conversion to psychosis in adolescents at high-risk.
作者信息
Walder D J, Mittal V, Trotman H D, McMillan A L, Walker E F
机构信息
Department of Psychology, Brooklyn College of The City University of New York, USA.
出版信息
Schizophr Res. 2008 Apr;101(1-3):161-8. doi: 10.1016/j.schres.2007.12.477. Epub 2008 Feb 20.
Abstract
This study examined neurocognitive predictors of conversion to Axis I psychosis among adolescents at high-risk for psychosis (AHRP). There were no significant differences in neurocognitive performance between adolescents at high-risk for psychosis who converted (AHRP+) and adolescents at high-risk for psychosis who did not convert (AHRP-). Within-sex comparisons revealed a relation between risk status and performance among females, with AHRP+ performing below AHRP-, but this effect did not hold for males. Between-sex comparisons revealed AHRP- males performed worse than AHRP- females on several measures. Across groups, males performed better than their female counterparts on select measures. Results are discussed in terms of implications for use of neurocognitive profiles as bio-risk markers of psychosis, while considering sex differences.
摘要
本研究调查了精神病高危青少年（AHRP）中转化为轴I型精神病的神经认知预测因素。转化的精神病高危青少年（AHRP+）与未转化的精神病高危青少年（AHRP-）在神经认知表现上没有显著差异。性别内比较显示，女性的风险状态与表现之间存在关联，AHRP+的表现低于AHRP-，但这种效应在男性中不成立。性别间比较显示，在多项测量中，AHRP-男性的表现比AHRP-女性差。在所有组中，男性在某些测量上的表现优于女性对应者。在考虑性别差异的同时，根据将神经认知概况用作精神病生物风险标志物的意义对结果进行了讨论。
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