Hou Bob L, Bradbury Michelle, Peck Kyung K, Petrovich Nicole M, Gutin Philip H, Holodny Andrei I
Functional MRI Laboratory, Box 506, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Neuroimage. 2006 Aug 15;32(2):489-97. doi: 10.1016/j.neuroimage.2006.04.188. Epub 2006 Jun 27.
We utilized blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) and MR perfusion imaging methods to study the influence of brain tumor neovascularity on the BOLD fMRI activation volume in the primary motor cortex (PMC). The results from 57 brain tumor cases demonstrated that, for grade IV gliomas only, decreases in the BOLD fMRI activation volumes within the ipsilateral PMC, when compared with that observed in the contralateral PMC, correlated with increases in the relative regional cerebral blood volume (rCBV) in the PMC. In addition, relative increases in the activation volumes, corresponding to decreases in the rCBV, exhibited a linear dependence on the distance between the grade IV glioma and PMC. These findings lend support to the hypothesis that decreases in the fMRI activation volumes adjacent to a GBM may, in part, be due to the increased contribution of aberrant tumor neovascularity, with the resultant de-coupling of blood flow from neuronal activity. The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC.
我们利用血氧水平依赖（BOLD）功能磁共振成像（fMRI）和磁共振灌注成像方法，研究脑肿瘤新生血管对初级运动皮层（PMC）中BOLD fMRI激活体积的影响。57例脑肿瘤病例的结果表明，仅对于IV级胶质瘤，与对侧PMC相比，同侧PMC内BOLD fMRI激活体积的减少与PMC中相对局部脑血容量（rCBV）的增加相关。此外，对应于rCBV减少的激活体积的相对增加，表现出对IV级胶质瘤与PMC之间距离的线性依赖性。这些发现支持了这样的假设，即与胶质母细胞瘤相邻的fMRI激活体积的减少，部分可能是由于异常肿瘤新生血管的贡献增加，导致血流与神经元活动解耦。由此产生的激活体积与相邻肿瘤特征之间关系的性质很复杂，但发现它取决于肿瘤的分级和类型，以及肿瘤与PMC的距离。
