Nutt Stephen L, Fairfax Kirsten A, Kallies Axel
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria, 3050, Australia.
Nat Rev Immunol. 2007 Dec;7(12):923-7. doi: 10.1038/nri2204.
B-lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor, and its importance in controlling the terminal differentiation of antibody-secreting cells (ASCs) is well established. However, as we discuss in this Progress article, it has now become evident that the ASC programme consists of a discrete BLIMP1-independent initiation phase, followed by a second step in which BLIMP1 is absolutely required for the differentiation of fully mature ASCs. In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells.
B淋巴细胞诱导成熟蛋白1（BLIMP1）是一种转录抑制因子，其在控制抗体分泌细胞（ASC）终末分化中的重要性已得到充分证实。然而，正如我们在这篇进展文章中所讨论的，现在已经很明显，ASC程序包括一个独立于BLIMP1的起始阶段，随后是第二步，在这一步中，BLIMP1对于完全成熟的ASC的分化是绝对必需的。此外，BLIMP1在维持效应T细胞稳态中的重要作用正在显现，这表明B细胞和T细胞中效应细胞命运控制之间存在有趣的相似之处。
