Medford A R L, Millar A B
Lung Research Group, Department of Clinical Science at North Bristol, University of Bristol Lifeline Centre, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
Thorax. 2006 Jul;61(7):621-6. doi: 10.1136/thx.2005.040204.
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), remains a devastating condition with a high mortality. It is characterised by alveolar injury and increased pulmonary vascular permeability. Vascular endothelial cell growth factor (VEGF) was identified by its properties to increase permeability and act as a cellular growth factor, hence its potential for a key role in the pathogenesis of ALI/ARDS. This review describes the basic biology of VEGF and its receptors as an essential prerequisite to discussing the available and sometimes paradoxical published data, before considering a paradigm for the role of VEGF in the human lung.
急性呼吸窘迫综合征（ARDS）是急性肺损伤（ALI）最严重的形式，仍然是一种具有高死亡率的毁灭性疾病。它的特征是肺泡损伤和肺血管通透性增加。血管内皮细胞生长因子（VEGF）因其增加通透性和作为细胞生长因子的特性而被识别，因此其在ALI/ARDS发病机制中具有关键作用的潜力。在探讨VEGF在人类肺部作用的范例之前，本综述描述了VEGF及其受体的基本生物学特性，这是讨论现有且有时相互矛盾的已发表数据的必要前提。
