Luo Qifeng, Shen Ningning, Liang Jingtian, Qin Xichun, Feng Shoujie, Chen Yuting, Xu Lei
Department of Thoracic Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Sci Rep. 2025 Jan 9;15(1):1420. doi: 10.1038/s41598-025-86003-0.
Acute respiratory distress syndrome (ARDS) has a high mortality rate worldwide; thus, identifying death risk factors related to ARDS is critical for risk stratification in patients with ARDS. In the present study, we conducted a single-center retrospective cohort analysis. Out of 278 patients with ARDS admitted from January 2016 to June 2022, 226 were included in this study. The patients were classified based on whether they were alive or dead during hospitalization. Their demographic and laboratory data and results were analyzed by performing a standard statistical analysis. Patients in the death group were older, with worse respiratory functions and blood biochemistry than those in the non-death group. Moreover, statistically significant differences were observed in the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) between the two groups. Multivariate stepwise logistic regression analysis showed that the VEGF/PEDF ratio was strongly associated with the risk of death. The area under the curve of the VEGF/PEDF ratio was 0.829 (95% confidence interval: 0.772-0.885; P < 0.001), sensitivity was 86.3%, and specificity was 68.0%. Therefore, a VEGF/PEDF ratio is positively correlated with the risk of death in patients with ARDS.
急性呼吸窘迫综合征（ARDS）在全球范围内死亡率很高；因此，识别与ARDS相关的死亡风险因素对于ARDS患者的风险分层至关重要。在本研究中，我们进行了一项单中心回顾性队列分析。在2016年1月至2022年6月收治的278例ARDS患者中，本研究纳入了226例。根据患者住院期间的存活或死亡情况进行分类。通过标准统计分析对他们的人口统计学和实验室数据及结果进行分析。死亡组患者年龄更大，呼吸功能和血液生化指标比非死亡组更差。此外，两组之间血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）水平存在统计学显著差异。多因素逐步逻辑回归分析表明，VEGF/PEDF比值与死亡风险密切相关。VEGF/PEDF比值的曲线下面积为0.829（95%置信区间：0.772 - 0.885；P < 0.001），敏感性为86.3%，特异性为68.0%。因此，VEGF/PEDF比值与ARDS患者的死亡风险呈正相关。
