Lunardelli A, Leite C E, Pires M Guerra Simões, de Oliveira J Rodrigues
Laboratório de Pesquisa em Biofísica, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga 6681 prédio 12C sala 263, CEP 90619-900, Porto Alegre, RS, Brazil.
Inflamm Res. 2006 Apr;55(4):129-35. doi: 10.1007/s00011-006-0008-x.
In the present study we assessed the inflammatory potential of venom obtained from caterpillar genus Dirphia in an acute model of lung injury.
Injection of extract from the bristles of Dirphia sp. (EBD) into the pleural cavity of rats elicited an acute inflammation response characterized by fluid accumulation which contained a large number of polymorphonuclear neutrophils (PMNs).
The results show that EBD induces an inflammatory response, with a significant increase in PMNs, exudate and nitric oxide within 4 h after a 0.04 mg/kg dose. The administration of anti-inflammatory drugs (fructose-1,6-bisphosphate, dexamethasone, rofecoxib, sodium diclofenac and pyrilamine) significantly reduced the inflammatory effect of EBD.
EBD causes an inflammatory reaction in the pleural cavity of rats involving a variety of inflammatory mediators, its action mechanism probably involving cellular injury and the exacerbated induction of cytokines and nitric oxide.
在本研究中，我们在急性肺损伤模型中评估了从迪尔菲亚毛虫属获取的毒液的炎症潜力。
将迪尔菲亚属刚毛提取物（EBD）注射到大鼠胸腔内引发急性炎症反应，其特征为液体蓄积，其中含有大量多形核中性粒细胞（PMN）。
结果表明，在0.04mg/kg剂量后4小时内，EBD诱导炎症反应，PMN、渗出液和一氧化氮显著增加。给予抗炎药物（1,6-二磷酸果糖、地塞米松、罗非昔布、双氯芬酸钠和吡拉明）可显著降低EBD的炎症作用。
EBD在大鼠胸腔内引起炎症反应，涉及多种炎症介质，其作用机制可能涉及细胞损伤以及细胞因子和一氧化氮的过度诱导。
