Laboratório de Microbiologia Clínica, Centro Universitário Franciscano (UNIFRA), Santa Maria, Rio Grande do Sul, Brasil.
Inflammation. 2010 Jun;33(3):173-9. doi: 10.1007/s10753-009-9171-x.
The following study aimed to evaluate, in vitro and in vivo, the anti-inflammatory effect of Ulomoides dermestoides, a beetle commonly used as a remedy for a variety of diseases including respiratory disorders and asthma. We used an acute inflammation model of injury, injection of carrageenan into the pleural cavity of rats. The rats were treated intraperitoneally with the aqueous extract of U. dermestoides 8 and 16 mg/kg. The exudate volume, protein concentration, polymorphonuclear leukocytes (PMNs) and total leukocyte were measured. The peripheral blood mononuclear cells (PBMCs) were isolated from the blood of healthy subjects and we investigated the immunomodulatory and cytotoxic effect of aqueous extract of U. dermestoides. In conclusion, in vitro we observed a non-cytotoxic effect and antiproliferative activity on the dose of 12.5 mg/dL. In vivo, this paper clarifies the great clinical relevance of the aqueous extract of U. dermestoides in elucidating its role as an anti-inflammatory agent.
本研究旨在评估鞘翅目多足类昆虫地鳖（Ulomoides dermestoides）的抗炎作用，地鳖常被用作治疗多种疾病的药物，包括呼吸道疾病和哮喘。我们使用了一种急性炎症损伤模型，向大鼠的胸腔内注射角叉菜胶。大鼠经腹腔内给予地鳖 8 和 16 mg/kg 的水提物。测量渗出液体积、蛋白浓度、多形核白细胞（PMN）和总白细胞数。从健康受试者的血液中分离外周血单核细胞（PBMC），并研究地鳖水提物的免疫调节和细胞毒性作用。总之，我们在体外观察到非细胞毒性作用和在 12.5 mg/dL 剂量下的抗增殖活性。在体内，本文阐明了地鳖水提物在阐明其作为抗炎剂方面的巨大临床相关性。
