van Eeden S P, Bütow K
John Radcliffe Hospital, Headley Way, Headington, Oxford, UK.
SADJ. 2006 May;61(4):154-9.
Pain, swelling and dry socket formation commonly follow third molar surgery. The objective was to investigate the effect of intrasocket Covomycin D, an antibiotic/anti-inflammatory medication, on pain, swelling and dry socket following lower third molar removal. Nineteen subjects had bilateral lower third molars removed. The patients were blinded to the side of medication; the opposite side acted as the control; post-operatively a pain visual analogue scale was completed, the side of the worst swelling and the incidence of dry socket noted. The data was analysed using the Wilcoxons matched pairs signed ranks test. Results showed that the pain score was lower for the medicated side in 11 patients on day one and in 16 patients over the six day post-operative period (p < 0.6). The swelling was less on the medicated side in fourteen patients. Three dry sockets developed in non-medicated sockets. In conclusion this study shows that the use of intra-socket Covomycin D favourably influences post-operative sequelae following lower third molar removal.
疼痛、肿胀和干槽症的形成通常发生在第三磨牙手术后。目的是研究牙槽窝内注入抗生素/抗炎药物Covomycin D对下颌第三磨牙拔除术后疼痛、肿胀和干槽症的影响。19名受试者双侧下颌第三磨牙被拔除。患者对用药侧不知情；另一侧作为对照；术后完成疼痛视觉模拟量表，记录肿胀最严重的一侧和干槽症的发生率。使用Wilcoxons配对符号秩检验分析数据。结果显示，用药侧在术后第1天有11名患者疼痛评分较低，在术后6天内有16名患者疼痛评分较低（p<0.6）。用药侧有14名患者肿胀较轻。非用药侧牙槽窝出现3例干槽症。总之，本研究表明牙槽窝内使用Covomycin D对下颌第三磨牙拔除术后的后遗症有积极影响。
