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本文引用的文献

1
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency.
J Am Vet Med Assoc. 2002 Dec 15;221(12):1716-8, 1714. doi: 10.2460/javma.2002.221.1716.
2
Inheritance of pancreatic acinar atrophy in German Shepherd Dogs.
Am J Vet Res. 2002 Oct;63(10):1429-34. doi: 10.2460/ajvr.2002.63.1429.
3
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency.外分泌性胰腺功能不全犬长期酶替代治疗的反应
J Am Vet Med Assoc. 1998 Jul 1;213(1):86-90.
4
High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis.高剂量胰酶补充剂与囊性纤维化患儿的纤维性结肠病
N Engl J Med. 1997 May 1;336(18):1283-9. doi: 10.1056/NEJM199705013361803.
5
High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis.高强度胰酶补充剂与囊性纤维化患者的大肠狭窄
Lancet. 1994 Jan 8;343(8889):110.
6
Bacterial overgrowth in the duodenum of dogs with exocrine pancreatic insufficiency.
J Am Vet Med Assoc. 1987 Jul 15;191(2):201-6.
7
Mesenteric torsion in dogs with exocrine pancreatic insufficiency: 21 cases (1978-1987).患有外分泌性胰腺功能不全的犬的肠系膜扭转：21例（1978 - 1987年）
J Am Vet Med Assoc. 1989 Nov 15;195(10):1404-6.
8
Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis.囊性纤维化患者高剂量胰腺提取物治疗导致的高尿酸尿症。
N Engl J Med. 1976 Jul 29;295(5):246-8. doi: 10.1056/NEJM197607292950503.

一只患有胰腺腺泡萎缩的德国牧羊犬在补充胰酶后出现口腔溃疡和出血。

Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy.

作者信息

Snead Elisabeth

机构信息

Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

出版信息

Can Vet J. 2006 Jun;47(6):579-82.

PMID:16808232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1461413/
Abstract

A 20-month-old German shepherd with primary pancreatic acinar atrophy and exocrine pancreatic insufficiency that was treated with pancreatic enzyme supplementation, vitamin B12, and cimetidine developed oral bleeding. Following discontinuation of the cimetidine, increased preincubation of the enzymes with the food, and symptomatic therapy for the ulceration, the dog's condition improved.

摘要

一只20个月大的德国牧羊犬患有原发性胰腺腺泡萎缩和外分泌性胰腺功能不全，接受了胰酶补充剂、维生素B12和西咪替丁治疗，之后出现口腔出血。停用西咪替丁、增加酶与食物的预孵育时间并对溃疡进行对症治疗后，这只狗的状况有所改善。