Gladstone Gemma L, Parker Gordon B
School of Psychiatry, University of New South Wales and Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales, 2031, Australia.
J Affect Disord. 2006 Oct;95(1-3):85-94. doi: 10.1016/j.jad.2006.04.015. Epub 2006 Jun 30.
Several studies have reported an observed relationship between a behaviorally inhibited temperament early in life and subsequent clinical anxiety, but few have explored the relationship between early inhibition and depression.
In a cross-sectional survey of non-clinical adults we examined the relationship between retrospectively reported childhood behavioral inhibition and lifetime depression. We then examined the mediating role of social anxiety and childhood relational stress factors.
Subjects who qualified for a lifetime episode of depression also reported significantly more childhood inhibition, particularly if they had a juvenile onset depression (i.e., by age 16). Further analyses revealed that social anxiety mediated the link between reported childhood inhibition and later depression, and highlighted the additional meditating effect of parental influences.
Any relationship between an early inhibited temperament and later depression, may in fact be dependent upon the presence of clinically meaningful social anxiety.
多项研究报告了生命早期行为抑制性气质与随后临床焦虑之间的观察到的关系，但很少有研究探讨早期抑制与抑郁之间的关系。
在一项针对非临床成年人的横断面调查中，我们研究了回顾性报告的童年行为抑制与终生抑郁之间的关系。然后我们研究了社交焦虑和童年关系压力因素的中介作用。
符合终生抑郁发作标准的受试者也报告了更多的童年抑制，特别是如果他们患有青少年期抑郁症（即16岁之前发病）。进一步分析表明，社交焦虑介导了报告的童年抑制与后期抑郁之间的联系，并突出了父母影响的额外中介作用。
早期抑制性气质与后期抑郁之间的任何关系，实际上可能取决于临床上有意义的社交焦虑的存在。
