Rocha Eduardo P C
Unité Génomique des Génomes Bactériens, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France.
Trends Genet. 2006 Aug;22(8):412-6. doi: 10.1016/j.tig.2006.06.004. Epub 2006 Jun 30.
The sequences of proteins change at dramatically different rates. Unraveling the association between this variability and cellular and ecological processes will enable a better understanding of protein function and evolution. Although weak associations of protein evolutionary rates with a plethora of variables have been reported, none withstands comparison with the effect of expression levels. A recent report by Drummond et al. suggests that the dominant role of expression levels in slowing the rate of protein evolution stems from selection for translation robustness.
蛋白质序列以截然不同的速率发生变化。揭示这种变异性与细胞及生态过程之间的关联，将有助于更好地理解蛋白质的功能与进化。尽管已有报道称蛋白质进化速率与众多变量之间存在微弱关联，但与表达水平的影响相比，这些关联均难以成立。德拉蒙德等人最近的一份报告表明，表达水平在减缓蛋白质进化速率方面的主导作用源于对翻译稳健性的选择。
