Park Donghyun, Choi Sun Shim
Howard Huges Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL, USA.
FEBS Lett. 2009 Apr 2;583(7):1053-9. doi: 10.1016/j.febslet.2009.02.033. Epub 2009 Feb 28.
Protein evolutionary rates have been presumed to be mostly determined by the density of functionally important amino acids in a given protein. They have been shown to correlate with variables intuitively related to functional importance of proteins, such as protein dispensability and protein-protein interactions. Surprisingly, the best correlate of the evolutionary rates has turned out to be not the functional importance of a protein, but the expression level of the protein. Drummond and Wilke suggest that the dominant role of expression levels in slowing the rate of protein evolution stems from a selection pressure against mistranslation-induced protein misfolding. We will review current evidence for and against different hypotheses on determining evolutionary rates.
蛋白质的进化速率一直被认为主要由特定蛋白质中功能重要氨基酸的密度决定。研究表明，它们与直观上与蛋白质功能重要性相关的变量相关，如蛋白质的可 dispensability 和蛋白质 - 蛋白质相互作用。令人惊讶的是，进化速率的最佳相关因素并非蛋白质的功能重要性，而是蛋白质的表达水平。Drummond 和 Wilke 认为，表达水平在减缓蛋白质进化速率方面的主导作用源于对误译诱导的蛋白质错误折叠的选择压力。我们将回顾支持和反对关于确定进化速率的不同假设的当前证据。
