在接受静脉注射蔗糖铁的血液透析患者中，非转铁蛋白结合铁与金黄色葡萄球菌生长增强有关。
Non-transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose.
作者信息
Barton Pai Amy, Pai Manjunath P, Depczynski Joseph, McQuade Charles R, Mercier Renee-Claude
机构信息
University of New Mexico College of Pharmacy, Albuquerque, NM 87131, USA.
出版信息
Am J Nephrol. 2006;26(3):304-9. doi: 10.1159/000094343. Epub 2006 Jun 29.
BACKGROUND
Hemodialysis vascular access infections are most frequently caused by Staphylococcus spp. The purpose of this study was to determine if S. aureus growth is enhanced after administration of IV iron sucrose and to establish a relationship between the appearance of non-transferrin-bound iron (NTBI) and S. aureus growth.
METHODS
Serum samples were obtained from 12 hemodialysis patients receiving maintenance doses of 100 mg of iron sucrose at baseline and 5, 30, 90, 220 min and 48 h after iron administration. Assays for NTBI and transferrin saturation were performed. S. aureus isolates were used to inoculate patient serum samples. Bacterial growth was determined by optical density.
RESULTS
Six of 12 patients had NTBI present within 30 min of the iron dose. NTBI was present more frequently in patients with baseline transferrin saturation values >30% (p < 0.05). Bacterial growth was significantly greater in patients who had NTBI present at 5, 90 and 220 min after iron administration compared to those who did not have NTBI present.
CONCLUSIONS
Doses of 100 mg of iron sucrose are associated with the presence of NTBI and enhanced S. aureus growth.
背景
血液透析血管通路感染最常见的原因是葡萄球菌属。本研究的目的是确定静脉注射蔗糖铁后金黄色葡萄球菌的生长是否会增强，并确定非转铁蛋白结合铁（NTBI）的出现与金黄色葡萄球菌生长之间的关系。
方法
从12名接受维持剂量100mg蔗糖铁的血液透析患者中获取血清样本，分别在基线时以及铁剂给药后5、30、90、220分钟和48小时采集。进行NTBI和转铁蛋白饱和度检测。使用金黄色葡萄球菌分离株接种患者血清样本。通过光密度测定细菌生长情况。
结果
12名患者中有6名在铁剂给药后30分钟内出现NTBI。基线转铁蛋白饱和度值>30%的患者中NTBI出现的频率更高（p<0.05）。与未出现NTBI的患者相比，在铁剂给药后5、90和220分钟出现NTBI的患者细菌生长明显更旺盛。
结论
100mg蔗糖铁剂量与NTBI的出现以及金黄色葡萄球菌生长增强有关。
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