Pilkington K, Kirkwood G, Rampes H, Fisher P, Richardson J
School of Integrated Health, University of Westminster, London, UK.
Homeopathy. 2006 Jul;95(3):151-62. doi: 10.1016/j.homp.2006.05.005.
To conduct a systematic review of the clinical research evidence on homeopathy in the treatment of anxiety and anxiety disorders.
A comprehensive search of major biomedical databases: MEDLINE, EMBASE, ClNAHL, PsycINFO, Cochrane Library; and of specialist complementary and alternative medicine (CAM) databases: AMED, CISCOM and Hom-Inform was conducted. Efforts were made to identify unpublished and ongoing research using relevant sources and experts in the field. Relevant research was categorised by study type and appraised according to study design. Clinical commentaries were obtained for studies reporting clinical outcomes.
Eight randomised controlled studies were identified. The types of anxiety and anxiety disorders studied were test anxiety, generalised anxiety disorder and anxiety related to medical or physical conditions such as cancer or surgical procedures. Single case reports/studies were the most frequently encountered study type but other study types including uncontrolled trials/case series and surveys were also found. No relevant qualitative research was identified.
A comprehensive search demonstrates that the evidence on the benefit of homeopathy in anxiety and anxiety disorders is limited. A number of studies of homeopathy in such conditions were located but the randomised controlled trials report contradictory results, are underpowered or provide insufficient details of methodology. Several uncontrolled and observational studies reported positive results including high levels of patient satisfaction but because of the lack of a control group, it is difficult to assess the extent to which any response is due to homeopathy. Adverse effects reported appear limited to 'remedy reactions' and included temporary worsening of symptoms and reappearance of old symptoms. On the basis of this review it is not possible to draw firm conclusions on the efficacy or effectiveness of homeopathy for anxiety. However, surveys suggest that homeopathy is quite frequently used by people suffering from anxiety. If shown to be effective, it is possible that homeopathy may have benefits in terms of adverse effects and acceptability to patients. Consequently, further investigation is indicated. Future research should be of pragmatic design and include qualitative studies.
对顺势疗法治疗焦虑症及焦虑障碍的临床研究证据进行系统评价。
全面检索主要生物医学数据库：MEDLINE、EMBASE、护理学与健康领域数据库（CINAHL）、心理学文摘数据库（PsycINFO）、考克兰图书馆；以及专业补充和替代医学（CAM）数据库：澳大利亚补充医学数据库（AMED）、补充医学信息系统（CISCOM）和顺势疗法信息库（Hom-Inform）。通过相关来源和该领域专家努力识别未发表和正在进行的研究。相关研究按研究类型分类，并根据研究设计进行评估。对于报告临床结果的研究获取临床评论。
识别出8项随机对照研究。所研究的焦虑症及焦虑障碍类型包括考试焦虑、广泛性焦虑障碍以及与癌症或外科手术等医学或身体状况相关的焦虑。单病例报告/研究是最常遇到的研究类型，但也发现了其他研究类型，包括非对照试验/病例系列和调查。未识别出相关的定性研究。
全面检索表明，顺势疗法治疗焦虑症及焦虑障碍有益的证据有限。找到了一些关于顺势疗法治疗此类病症的研究，但随机对照试验报告结果相互矛盾、样本量不足或方法学细节提供不充分。一些非对照和观察性研究报告了积极结果，包括患者满意度高，但由于缺乏对照组，难以评估任何反应在多大程度上归因于顺势疗法。报告的不良反应似乎仅限于“药物反应”，包括症状暂时加重和旧症状重现。基于本综述，无法就顺势疗法治疗焦虑的疗效或有效性得出确凿结论。然而，调查表明焦虑症患者相当频繁地使用顺势疗法。如果证明有效，顺势疗法在不良反应和患者可接受性方面可能具有优势。因此，需要进一步研究。未来的研究应采用实用设计并包括定性研究。
