视网膜母细胞瘤肿瘤抑制因子：癌症与细胞周期的交汇点
Retinoblastoma tumor suppressor: where cancer meets the cell cycle.
作者信息
Knudsen Erik S, Knudsen Karen E
机构信息
Department of Cell Biology and University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio 45267-0521, USA.
出版信息
Exp Biol Med (Maywood). 2006 Jul;231(7):1271-81. doi: 10.1177/153537020623100713.
PMID:16816134
Abstract
The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.
摘要
视网膜母细胞瘤抑癌基因Rb是首个被鉴定出的抑癌基因，在调控细胞周期进程中发挥着重要作用。本综述详细阐述了RB蛋白在细胞周期控制中的功能方面，并聚焦于那些仍是深入研究热点的具体问题。
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