Forman Robert F, Woody George E, McLellan Thomas, Lynch Kevin G
Medical Affairs Alkermes, Inc., 88 Sidney St., Cambridge, MA 02139, USA.
Am J Psychiatry. 2006 Jul;163(7):1233-8. doi: 10.1176/ajp.2006.163.7.1233.
This study was designed to determine the availability of web sites offering to sell opioid medications without prescriptions.
Forty-seven Internet searches were conducted with a variety of opioid medication terms, including "codeine," "no prescription Vicodin," and "OxyContin." Two independent raters examined the links generated in each search and resolved any coding disagreements. The resulting links were coded as "no prescription web sites" (NPWs) if they offered to sell opioid medications without prescriptions.
In searches with terms such as "no prescription codeine" and "Vicodin," over 50% of the links obtained were coded as "NPWs." The proportion of links yielding NPWs was greater when the phrase "no prescription" was added to the opioid term. More than 300 opioid NPWs were identified and entered into a database.
Three national drug-use monitoring studies have cited significant increases in prescription opioid use over the past 5 years, particularly among young people. The emergence of NPWs introduces a new vector for unregulated access to opioids. Research is needed to determine the effect of NPWs on prescription opioid use initiation, misuse, and dependence.
本研究旨在确定提供无处方销售阿片类药物的网站的可获取性。
使用多种阿片类药物术语进行了47次互联网搜索,包括“可待因”“无需处方的维柯丁”和“奥施康定”。两名独立评估人员检查了每次搜索生成的链接,并解决了任何编码分歧。如果链接提供无处方销售阿片类药物,则将其编码为“无处方网站”(NPW)。
在使用“无需处方的可待因”和“维柯丁”等术语进行的搜索中,超过50%的获得的链接被编码为“NPW”。当在阿片类药物术语中添加“无需处方”短语时,产生NPW的链接比例更高。识别出300多个阿片类NPW并录入数据库。
三项全国性药物使用监测研究表明,在过去5年中,处方阿片类药物的使用显著增加,尤其是在年轻人中。无处方网站的出现为无管制获取阿片类药物引入了一种新途径。需要开展研究以确定无处方网站对处方阿片类药物使用起始、滥用和依赖的影响。