Melbourne Dental School, University of Melbourne, Carlton, Victoria, Australia.
School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia.
Sci Rep. 2020 May 21;10(1):8463. doi: 10.1038/s41598-020-65390-6.
The misuse of pharmaceutical opioids is a major public health issue. In Australia, codeine was re-scheduled on 1 February 2018 to restrict access; it is now only available on prescription. The aim of this study was to measure the change in dental opioid prescriptions, one year before and after the codeine re-scheduling in Australia and to assess dental prescribing rates of opioids for 2018 by population and by clinician. Data was extracted for dental opioids for the year immediately prior and after the codeine up-schedule (1 February 2017-31 January 2019) from the publicly-available national prescription database (Pharmaceutical Benefits Scheme). Descriptive statistics, T-tests and odds ratios were used to identify significant prescribing differences. Codeine, codeine/paracetamol, oxycodone and tramadol use increased significantly the year after the codeine restriction than the previous year (13.8-101.1%). Australian dentists prescribed 8.6 prescriptions/1,000 population in 2018, with codeine/paracetamol accounting for most prescriptions (96%). The significant increase in opioid prescribing highlights that Australian dentists may be contributing to the misuse of pharmaceutical opioids. Educational efforts should be targeted at the appropriate use of opioids and patient selection. Dentists should be added to the prescription monitoring system SafeScript so they can make informed decisions for patients who are potentially misusing opioids.
药物阿片类药物的滥用是一个主要的公共卫生问题。在澳大利亚,可待因于 2018 年 2 月 1 日重新进行了分类管制,以限制其获取途径;现在只能凭处方获得。本研究的目的是测量在澳大利亚可待因重新分类管制之前和之后一年中牙科阿片类药物处方的变化,并按人口和临床医生评估 2018 年牙科阿片类药物的处方率。从公开的国家处方数据库(药品福利计划)中提取了可待因调整前后一年(2017 年 2 月 1 日至 2019 年 1 月 31 日)的牙科阿片类药物数据。使用描述性统计、T 检验和优势比来确定显著的处方差异。可待因、可待因/对乙酰氨基酚、羟考酮和曲马多的使用在可待因限制后的一年显著增加(13.8-101.1%)。澳大利亚牙医在 2018 年开具了 8.6 份/1000 人的处方,其中可待因/对乙酰氨基酚占大多数处方(96%)。阿片类药物处方的显著增加表明,澳大利亚牙医可能在助长药物阿片类药物的滥用。应针对阿片类药物的合理使用和患者选择开展教育工作。应将牙医纳入处方监测系统 SafeScript,以便他们可以为可能滥用阿片类药物的患者做出明智的决策。