新型抗病毒药物。

New antiviral agents.

作者信息

Abdel-Haq Nahed, Chearskul Pimpanada, Al-Tatari Hossam, Asmar Basim

机构信息

Division of Infectious Diseases, Children's Hospital of Michigan, Carman and Ann Adams, Department of Pediatrics, Wayne State University, School of Medicine, Detroit 48201, USA.

出版信息

Indian J Pediatr. 2006 Apr;73(4):313-21. doi: 10.1007/BF02825826.

DOI:10.1007/BF02825826

PMID:16816493

Abstract

During the last three decades, a better understanding of viral replication and disease states caused by viral infections have led to the development of newer antiviral agents with enhanced activity and better tolerability. This review focuses on newer systemic and topical antiviral agents that are used in treatment of herpes viruses including herpes simplex type-1 (HSV-1) and type-2 (HSV-2), varicella-zoster virus (VZV) and cytomegalovirus CMV) as well as the human papilloma virus (HPV). Included in this article are the agents famciclovir, penciclovir, valganciclovir, imiquimod, docosanole and brivudin.

摘要

在过去三十年中，对病毒复制以及病毒感染所引发疾病状态的更深入了解，促使了活性更强、耐受性更好的新型抗病毒药物的研发。本综述聚焦于用于治疗疱疹病毒的新型全身性和局部性抗病毒药物，这些疱疹病毒包括单纯疱疹病毒1型（HSV-1）、2型（HSV-2）、水痘带状疱疹病毒（VZV）、巨细胞病毒（CMV）以及人乳头瘤病毒（HPV）。本文涵盖的药物有泛昔洛韦、喷昔洛韦、缬更昔洛韦、咪喹莫特、二十二碳醇和溴夫定。