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(亚)急性下背痛患者的预后预测因素在不同治疗组之间存在差异。

Predictors of outcome in patients with (sub)acute low back pain differ across treatment groups.

作者信息

Jellema Petra, van der Horst Henriëtte E, Vlaeyen Johan W S, Stalman Wim A B, Bouter Lex M, van der Windt Daniëlle A W M

机构信息

Department of General Practice, VU University Medical Center, Amsterdam, The Netherlands.

出版信息

Spine (Phila Pa 1976). 2006 Jul 1;31(15):1699-705. doi: 10.1097/01.brs.0000224179.04964.aa.

Abstract

STUDY DESIGN

Prospective study with 6 weeks of follow-up.

OBJECTIVE

To examine the predictors of outcome for patients with (sub)acute low back pain (LBP) receiving usual care (UC) or a minimal intervention strategy (MIS) aimed at psychosocial factors.

SUMMARY OF BACKGROUND DATA

A randomized controlled trial in general practice showed no differences in average effect between UC and MIS.

METHODS

Socio-demographic variables, characteristics of LBP, and psychosocial factors were included as potential predictors of outcome. The outcome clinically important improvement was defined as a reduction of at least 30% on functional disability plus patient perceived recovery. Logistic regression analyses were used to study the associations between predictors and outcome at 6 weeks follow-up.

RESULTS

In the UC group (n = 163), the multivariable model included a shorter duration of the LBP episode, few previous episodes, less pain catastrophizing, and good perceived general health. The area under the curve (AUC) of the model was 0.77 (95% confidence interval, 0.70-0.85). In the MIS group (n = 142), the multivariable model included less somatizing symptoms, more solicitous responses by an important other, lower perceived risk for chronic LBP, more fear avoidance beliefs, higher level of education, and shorter duration of the LBP episode. This AUC was 0.78 (95% confidence interval, 0.71-0.86).

CONCLUSIONS

As we found two different profiles, our approach may contribute to the important question: what intervention works for whom?

摘要

研究设计

为期6周随访的前瞻性研究。

目的

探讨接受常规护理(UC)或针对心理社会因素的最小干预策略(MIS)的(亚)急性腰痛(LBP)患者的预后预测因素。

背景数据总结

一项全科医学随机对照试验显示,UC和MIS之间的平均效果无差异。

方法

纳入社会人口统计学变量、LBP特征和心理社会因素作为预后的潜在预测因素。临床重要改善结局定义为功能障碍至少降低30%加上患者自我感觉恢复。采用逻辑回归分析研究随访6周时预测因素与结局之间的关联。

结果

在UC组(n = 163)中,多变量模型包括LBP发作持续时间较短、既往发作次数较少、疼痛灾难化程度较低以及自我感觉总体健康状况良好。该模型的曲线下面积(AUC)为0.77(95%置信区间,0.70 - 0.85)。在MIS组(n = 142)中,多变量模型包括躯体化症状较少、重要他人的关心反应较多、慢性LBP感知风险较低、恐惧回避信念较多、教育水平较高以及LBP发作持续时间较短。该AUC为0.78(95%置信区间, 0.71 - 0.86)。

结论

由于我们发现了两种不同的特征,我们的方法可能有助于回答这个重要问题:哪种干预措施对谁有效?

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