合成的促黑素释放抑制因子Pro-Leu-Gly-NH2对艾迪生病促肾上腺皮质激素分泌的抑制作用。

Suppression of ACTH secretion by synthetic MSH-release inhibiting factor Pro-Leu-Gly-NH2 in Addison's disease.

作者信息

Voigt K H, Fehm H L, Lang R E, Beinert K E, Pfeiffer E F

出版信息

Horm Metab Res. 1977 Mar;9(2):150-2. doi: 10.1055/s-0028-1093565.

Abstract

The regulation of release of MSH and ACTH seems to be closely related. The effect of Pro-Leu-Gly-NH2, the most active MSH-release inhibiting factor (MIF), was investigated on ACTH-hypersecretion in six patients suffering from primary adrenocortical insufficiency. MIF was infused at constant rates with stepwise increase in concentration (0.25 mg, 2.5 mg, 25.0 mg/30 min). Plasma ACTH-levels were measured radioimmunologically at 10 minutes intervals. In four cases there was a remarkable decrease (P less than 0.005) in the ACTH plasma level of more than 50% as compared to the elevated starting levels of 800 to 1400 pg/ml. It is concluded that under certain circumstances MIF could play a role in the regulation of ACTH-secretion.

摘要

促黑素（MSH）和促肾上腺皮质激素（ACTH）的释放调节似乎密切相关。研究了活性最强的促黑素释放抑制因子（MIF）——脯氨酸-亮氨酸-甘氨酸-酰胺（Pro-Leu-Gly-NH2）对6例原发性肾上腺皮质功能不全患者促肾上腺皮质激素分泌过多的影响。以恒定速率输注MIF，浓度逐步增加（0.25毫克、2.5毫克、25.0毫克/30分钟）。每隔10分钟用放射免疫法测定血浆促肾上腺皮质激素水平。4例患者的促肾上腺皮质激素血浆水平与起始升高水平800至1400皮克/毫升相比显著下降（P<0.005），降幅超过50%。得出的结论是，在某些情况下，MIF可能在促肾上腺皮质激素分泌的调节中发挥作用。