合成的巨噬细胞移动抑制因子对尼尔森综合征中的β-促黑素和促肾上腺皮质激素分泌过多没有影响。

Synthetic MIF has no effect on beta-MSH and ACTH hypersecretion in Nelson's syndrome.

作者信息

Donnadieu M, Laurent M F, Luton J P, Bricaire H, Girard F, Binoux M

出版信息

J Clin Endocrinol Metab. 1976 Jun;42(6):1145-8. doi: 10.1210/jcem-42-6-1145.

Abstract

The effect of synthetic MIF (H-Pro-Leu-Gly-NH2) on beta-MSH secretion was studied in five patients with Nelson's syndrome and in one patient with Addison's disease. Two milligrams of the tripetide were injected intravenously (1 mg in an acute injection, followed by a 30-minute-infusion of 1 mg in 20 ml of saline solution). No consistent effect could be observed during the 90-minute period after the beginning of the infusion. In the same patients, LVP stimulation and dexamethasone suppression tests brought about significant changes in the plasma beta-MSH and ACTH levels.

摘要

在5例尼尔森综合征患者和1例艾迪生病患者中研究了合成的巨噬细胞移动抑制因子（H-脯氨酸-亮氨酸-甘氨酸-氨基）对β-促黑素细胞激素分泌的影响。将2毫克该三肽静脉注射（一次急性注射1毫克，随后在20毫升盐溶液中30分钟输注1毫克）。在输注开始后的90分钟内未观察到一致的效果。在相同患者中，静脉输注血管加压素刺激试验和地塞米松抑制试验使血浆β-促黑素细胞激素和促肾上腺皮质激素水平发生了显著变化。