Drug Transitions Study, National Addiction Centre, The Maudsley, London, SE5 8AF, UK.
Drug Alcohol Rev. 1994;13(3):293-300. doi: 10.1080/09595239400185391.
This study investigates the extent to which heroin users are exposed to multiple forms of infection risk. Structured interviews were administered to a prospective network sample of 408 heroin users. Subjects were contracted in south London in a wide range of social settings by specially recruited privileged access interviewers. Most heroin users (74.5%) had been exposed to more than one infection risk factor and more than half of the sample had been exposed to three or more risk factors. HIV serostatus was primarily related to men having sex with men. Hepatitis B seropositive status was primarily related to the number of years injecting drugs. At this stage of the HIV epidemic in London, HIV infection among heroin users may be related more to homosexual risk behaviour than drug risk factors. Heroin injectors were at greater risk of infection than heroin chasers both through their sexual behaviour as well as through their injecting practices. Heroin users who refused to give a saliva sample for analysis were found to be more likely to engage in several health risk behaviours than those who provided samples. This finding has important methodological implications for seroprevalence surveys. Other implications of the results for prevention programmes aimed at health risk behaviours of heroin users are also discussed.
本研究调查了海洛因使用者接触多种感染风险的程度。对 408 名海洛因使用者进行了前瞻性网络样本的结构化访谈。通过专门招募的特权访问访谈者,在伦敦南部的各种社会环境中与研究对象签约。大多数海洛因使用者(74.5%)接触过不止一种感染风险因素,超过一半的样本接触过三种或更多的风险因素。HIV 血清阳性状态主要与男男性行为有关。乙型肝炎表面抗原阳性状态主要与吸毒年限有关。在伦敦 HIV 流行的现阶段,HIV 感染在海洛因使用者中可能与同性恋风险行为有关,而不是与吸毒因素有关。海洛因注射者比海洛因吸食者更有可能通过性行为和注射行为感染,因为他们的行为更具风险。与提供样本的人相比,拒绝提供唾液样本进行分析的海洛因使用者更有可能从事多种健康风险行为。这一发现对血清流行率调查具有重要的方法学意义。研究结果还讨论了针对海洛因使用者健康风险行为的预防计划的其他影响。