Sari Ismail, Akar Servet, Birlik Merih, Sis Banu, Onen Fatos, Akkoc Nurullah
Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
J Rheumatol. 2006 Jul;33(7):1411-4.
We describe a patient with rheumatoid arthritis who developed psoriasis during treatment with etanercept; psoriatic lesions resolved completely after the drug was discontinued, but returned on rechallenge. No such adverse skin reaction occurred after switching therapy to infliximab. Through a Medline search we identified 11 reports involving 32 patients who developed psoriasis/psoriasiform eruptions during therapy with tumor necrosis factor-alpha (TNF-alpha) inhibitors. All TNF-alpha blocking agents have been reported to lead to or exacerbate psoriasis. In some cases skin changes were severe enough to discontinue the medication.
我们描述了一名类风湿性关节炎患者，该患者在使用依那西普治疗期间出现了银屑病；停用该药后银屑病皮损完全消退，但再次用药时又复发。换用英夫利昔单抗治疗后未出现此类不良皮肤反应。通过医学文献数据库检索，我们确定了11篇报告，涉及32例在使用肿瘤坏死因子-α（TNF-α）抑制剂治疗期间出现银屑病/银屑病样皮疹的患者。据报道，所有TNF-α阻断剂均可导致或加重银屑病。在某些病例中，皮肤变化严重到足以停药。
