Kubo Takahiro, Matsui Yoshito, Goto Tomohiro, Yukata Kiminori, Endo Kenji, Sato Ryosuke, Tsutsui Takahiko, Yasui Natsuo
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Anticancer Res. 2006 May-Jun;26(3B):2253-7.
The magnetic resonance (MR) characteristics of parosteal lipomas with the HMGA2-LPP fusion transcripts are described.
The expression of HMGA2-LPP fusion transcripts was determined using the reverse transcription-polymerase chain reaction method.
MR images of two cases with the fusion transcripts, a 56-year-old man and a 50-year-old woman, revealed heterogeneous high signal intensities on T1- and T2-weighted images, showing heterogeneous curvilinear enhancement on fat-suppressed T1-weighted images after Gd-DTPA injection, which resembled those of well-differentiated liposarcomas.
Since the HMGA2-LPP fusion transcripts are exclusively detectable in benign mesenchymal tumors, testing HMGA2-LPP expression may be useful for differential diagnosis in cases of radiologically-suspected well-differentiated liposarcomas.
描述了具有HMGA2-LPP融合转录本的骨旁脂肪瘤的磁共振（MR）特征。
采用逆转录-聚合酶链反应法测定HMGA2-LPP融合转录本的表达。
两名具有融合转录本的患者（一名56岁男性和一名50岁女性）的MR图像显示，在T1加权和T2加权图像上呈不均匀高信号强度，在注射钆喷酸葡胺后脂肪抑制T1加权图像上呈不均匀曲线强化，类似于高分化脂肪肉瘤。
由于HMGA2-LPP融合转录本仅在良性间叶肿瘤中可检测到，检测HMGA2-LPP表达可能有助于对放射学怀疑的高分化脂肪肉瘤病例进行鉴别诊断。
