与HMGA2-LPP融合基因相关的骨旁脂肪瘤的MRI特征。
MRI characteristics of parosteal lipomas associated with the HMGA2-LPP fusion gene.
作者信息
Kubo Takahiro, Matsui Yoshito, Goto Tomohiro, Yukata Kiminori, Endo Kenji, Sato Ryosuke, Tsutsui Takahiko, Yasui Natsuo
机构信息
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
出版信息
Anticancer Res. 2006 May-Jun;26(3B):2253-7.
BACKGROUND
The magnetic resonance (MR) characteristics of parosteal lipomas with the HMGA2-LPP fusion transcripts are described.
PATIENTS AND METHODS
The expression of HMGA2-LPP fusion transcripts was determined using the reverse transcription-polymerase chain reaction method.
RESULTS
MR images of two cases with the fusion transcripts, a 56-year-old man and a 50-year-old woman, revealed heterogeneous high signal intensities on T1- and T2-weighted images, showing heterogeneous curvilinear enhancement on fat-suppressed T1-weighted images after Gd-DTPA injection, which resembled those of well-differentiated liposarcomas.
CONCLUSION
Since the HMGA2-LPP fusion transcripts are exclusively detectable in benign mesenchymal tumors, testing HMGA2-LPP expression may be useful for differential diagnosis in cases of radiologically-suspected well-differentiated liposarcomas.
背景
描述了具有HMGA2-LPP融合转录本的骨旁脂肪瘤的磁共振（MR）特征。
患者和方法
采用逆转录-聚合酶链反应法测定HMGA2-LPP融合转录本的表达。
结果
两名具有融合转录本的患者（一名56岁男性和一名50岁女性）的MR图像显示，在T1加权和T2加权图像上呈不均匀高信号强度，在注射钆喷酸葡胺后脂肪抑制T1加权图像上呈不均匀曲线强化，类似于高分化脂肪肉瘤。
结论
由于HMGA2-LPP融合转录本仅在良性间叶肿瘤中可检测到，检测HMGA2-LPP表达可能有助于对放射学怀疑的高分化脂肪肉瘤病例进行鉴别诊断。
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