Young A A, Wang M W, Cooper G J
Amylin Corporation, Department of Physiology, San Diego, CA 92121.
FEBS Lett. 1991 Oct 7;291(1):101-4. doi: 10.1016/0014-5793(91)81113-m.
Intravenous injections of 25.5 nmol rat amylin into fasted anesthetized rats caused a rapid increase in plasma lactate followed by an increase in plasma glucose; there was a transient fall in blood pressure. Subcutaneous injection of 25.5 nmol amylin also caused increases in lactate and glucose but did not change blood pressure. Similar responses were observed during somatostatin infusion and in the absence of changes in catecholamines. These results fit with a scheme in which amylin elicits muscle glycogenolysis, release of lactate, and increased hepatic gluconeogenesis due to increased supply of substrate.
给禁食麻醉的大鼠静脉注射25.5纳摩尔大鼠胰淀素，会导致血浆乳酸迅速增加，随后血浆葡萄糖增加；血压出现短暂下降。皮下注射25.5纳摩尔胰淀素也会导致乳酸和葡萄糖增加，但不会改变血压。在输注生长抑素期间以及儿茶酚胺无变化的情况下也观察到了类似反应。这些结果符合这样一种机制，即胰淀素通过增加底物供应引发肌肉糖原分解、乳酸释放和肝脏糖异生增加。
