de Tar Michael, Sanford Biggerstaff Julie
InCyte Pathology, PO Box 3405, Spokane, WA 99220-3405, USA.
Pediatr Dev Pathol. 2006 Mar-Apr;9(2):161-7. doi: 10.2350/08-05-0090.1. Epub 2006 Jun 16.
Malignant congenital tumors of fetal origin are rare lesions, the most common type being congenital neuroblastoma. Although prenatal diagnosis is possible in large tumors, occasionally the tumor will be diagnosed first by its metastatic involvement of the placenta. Placental metastases can reflect either maternal or fetal primary sites, and each has relatively specific patterns of placental involvement. We describe the clinical and pathologic features of a widely metastatic congenital renal rhabdoid tumor with its placental and autopsy findings, and include the immunohistochemical, cytogenetic, and ultrastructural features. The pathologic features of the placenta in congenital renal rhabdoid tumor with placental metastasis have not been previously described. The examination of the placenta in this case led to the initial diagnosis and obviated the need for additional diagnostic procedures.
胎儿起源的恶性先天性肿瘤是罕见病变，最常见的类型是先天性神经母细胞瘤。虽然大肿瘤有可能进行产前诊断，但偶尔肿瘤会首先通过其对胎盘的转移累及而被诊断出来。胎盘转移可反映母体或胎儿的原发部位，且每种情况都有相对特定的胎盘受累模式。我们描述了一例广泛转移的先天性肾横纹肌样瘤的临床和病理特征及其胎盘和尸检结果，包括免疫组化、细胞遗传学和超微结构特征。先天性肾横纹肌样瘤伴胎盘转移时胎盘的病理特征此前尚未见报道。对该病例胎盘的检查导致了初步诊断，避免了额外诊断程序的需要。
