用于微生物抗原血清学表征的免疫蛋白质组学进展。
Advances in immunoproteomics for serological characterization of microbial antigens.
作者信息
Falisse-Poirrier Nandini, Ruelle Virginie, ElMoualij Benaissa, Zorzi Danièle, Pierard Olivier, Heinen Ernst, De Pauw Edwin, Zorzi Willy
机构信息
Center of Research on Prion Proteins, Institute of Pharmacy-CHU, B36, Avenue de l'Hôpital 1, B-4000 University of Liège, Belgium.
出版信息
J Microbiol Methods. 2006 Dec;67(3):593-6. doi: 10.1016/j.mimet.2006.05.002. Epub 2006 Jul 5.
We propose a multi-dimensional strategy, associating immunodetection to a protein fractionating two-dimensional liquid chromatography tool, for serological characterization of microbial antigens. The originality of such immunoproteomic approaches resides in their application in large-scale studies for rapid serotyping of micro-organisms, evaluation of immunomes and could be proposed in the development and monitoring of vaccines.
我们提出了一种多维策略，将免疫检测与蛋白质二维液相色谱分离工具相结合，用于微生物抗原的血清学表征。这种免疫蛋白质组学方法的独特之处在于其在大规模研究中的应用，可用于微生物的快速血清分型、免疫组评估，并且可用于疫苗的研发和监测。
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