Goh V, Halligan S, Gartner L, Bassett P, Bartram C I
Intestinal Imaging Centre, St Mark's Hospital, Harrow, UK.
Br J Radiol. 2006 Jul;79(943):578-83. doi: 10.1259/bjr/18842556.
The purpose of this study was to determine if greater z-axis tumour coverage improves the reproducibility of quantitative colorectal cancer perfusion measurements using CT. A 65 s perfusion study was acquired following intravenous contrast administration in 10 patients with proven colorectal cancer using a four-detector row scanner. This was repeated within 48 h using identical technical parameters to allow reproducibility assessment. Quantitative tumour blood volume, blood flow, mean transit time and permeability measurements were determined using commercially available software (Perfusion 3.0; GE Healthcare, Waukesha, WI) for data obtained from a 5 mm z-axis tumour coverage, and from a 20 mm z-axis tumour coverage. Measurement reproducibility was assessed using Bland-Altman statistics, for a 5 mm z-axis tumour coverage, and 20 mm z-axis tumour coverage, respectively. The mean difference (95% limits of agreement) for blood volume, blood flow, mean transit time and permeability were 0.04 (-2.50 to +2.43) ml/100 g tissue; +8.80 (-50.5 to +68.0) ml/100 g tissue/min; -0.99 (-8.19 to +6.20) seconds; and +1.20 (-5.42 to +7.83) ml/100 g tissue/min, respectively, for a 5 mm coverage, and -0.04 (-2.61 to +2.53) ml/100 g tissue; +7.40 (-50.3 to +65.0) ml/100 g tissue/min; -2.46 (-12.61 to +7.69) seconds; and -0.23 (-8.31 to +7.85) ml/100 g tissue/min, respectively, for a 20 mm coverage, indicating similar levels of agreement. In conclusion, increasing z-axis coverage does not improve reproducibility of quantitative colorectal cancer perfusion measurements.
本研究的目的是确定更大的z轴肿瘤覆盖范围是否能提高使用CT进行定量结直肠癌灌注测量的可重复性。对10例经证实的结直肠癌患者使用四排探测器扫描仪在静脉注射造影剂后进行了65秒的灌注研究。在48小时内使用相同的技术参数重复进行，以评估可重复性。使用市售软件（Perfusion 3.0；通用电气医疗集团，威斯康星州沃基沙）对从5毫米z轴肿瘤覆盖范围和20毫米z轴肿瘤覆盖范围获得的数据进行定量肿瘤血容量、血流、平均通过时间和通透性测量。分别使用Bland-Altman统计方法评估5毫米z轴肿瘤覆盖范围和20毫米z轴肿瘤覆盖范围的测量可重复性。对于5毫米覆盖范围，血容量、血流、平均通过时间和通透性的平均差异（95%一致性界限）分别为0.04（-2.50至+2.43）ml/100g组织；+8.80（-50.5至+68.0）ml/100g组织/分钟；-0.99（-8.19至+6.20）秒；和+1.20（-5.42至+7.83）ml/100g组织/分钟，对于20毫米覆盖范围，分别为-0.04（-2.61至+2.53）ml/100g组织；+7.40（-50.3至+65.0）ml/100g组织/分钟；-2.46（-12.61至+7.69）秒；和-0.23（-8.31至+7.85）ml/100g组织/分钟，表明一致性水平相似。总之，增加z轴覆盖范围并不能提高定量结直肠癌灌注测量的可重复性。
