Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.
Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark.
Diagnostics (Basel). 2016 Jul 21;6(3):28. doi: 10.3390/diagnostics6030028.
The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies.
本研究旨在提供关于动态对比增强计算机断层扫描（DCE-CT）作为评估肺癌患者治疗反应的工具的文献综述。本系统评价根据系统评价和荟萃分析的首选报告项目（PRISMA）指南编制。仅纳入使用 DCE-CT 评估肺癌患者治疗反应的原始研究文章。为了评估每项研究的有效性，我们实施了诊断准确性研究的质量评估（QUADAS-2）。最初的搜索产生了 651 篇出版物，其中 16 篇文章被纳入本研究。这些文章分为治疗组。在对接受系统化疗联合或不联合抗血管生成药物治疗的患者进行的研究中，7 项研究中有 4 项发现治疗后通透性显著下降。在测量抗血管生成治疗后血流的 5 项研究中，有 4 项发现血流明显减少。DCE-CT 可能是评估肺癌患者治疗反应的有用工具。似乎通透性和血流特别重要，是预测治疗结果的灌注值。然而，扫描方案、扫描参数和扫描之间的时间的异质性使得比较纳入的研究变得困难。
