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在乙醇中用紫外光对棕榈酸视黄酯进行光辐照——光分解产物、活性氧和脂质过氧化物的形成。

Photoirradiation of retinyl palmitate in ethanol with ultraviolet light--formation of photodecomposition products, reactive oxygen species, and lipid peroxides.

作者信息

Xia Qingsu, Yin Jun J, Wamer Wayne G, Cherng Shu-Hui, Boudreau Mary D, Howard Paul C, Yu Hongtao, Fu Peter P

机构信息

National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

出版信息

Int J Environ Res Public Health. 2006 Jun;3(2):185-90. doi: 10.3390/ijerph2006030021.

DOI:10.3390/ijerph2006030021
PMID:16823091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3807509/
Abstract

We have previously reported that photoirradiation of retinyl palmitate (RP), a storage and ester form of vitamin A (retinol), with UVA light resulted in the formation of photodecomposition products, generation of reactive oxygen species, and induction of lipid peroxidation. In this paper, we report our results following the photoirradiation of RP in ethanol by an UV lamp with approximately equal UVA and UVB light. The photodecomposition products were separated by reversed-phase HPLC and characterized spectroscopically by comparison with authentic standards. The identified products include: 4-keto-RP, 11-ethoxy-12-hydroxy-RP, 13-ethoxy-14-hydroxy-RP, anhydroretinol (AR), and trans- and cis-15-ethoxy-AR. Photoirradiation of RP in the presence of a lipid, methyl linoleate, resulted in induction of lipid peroxidation. Lipid peroxidation was inhibited when sodium azide was present during photoirradiation which suggests free radicals were formed. Our results demonstrate that, similar to irradiation with UVA light, RP can act as a photosensitizer leading to free radical formation and induction of lipid peroxidation following irradiation with UVB light.

摘要

我们之前报道过，用UVA光照射视黄醇棕榈酸酯（RP，维生素A（视黄醇）的一种储存和酯形式）会导致光分解产物的形成、活性氧的产生以及脂质过氧化的诱导。在本文中，我们报告了用具有大致相等UVA和UVB光的紫外线灯对乙醇中的RP进行光照射后的结果。光分解产物通过反相高效液相色谱法分离，并通过与标准品比较进行光谱表征。鉴定出的产物包括：4-酮-RP、11-乙氧基-12-羟基-RP、13-乙氧基-14-羟基-RP、脱水视黄醇（AR）以及反式和顺式-15-乙氧基-AR。在脂质亚油酸甲酯存在的情况下对RP进行光照射会导致脂质过氧化的诱导。当在光照射期间存在叠氮化钠时脂质过氧化受到抑制，这表明形成了自由基。我们的结果表明，与用UVA光照射类似，RP可以作为一种光敏剂，在UVB光照射后导致自由基形成和脂质过氧化的诱导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/0a191067b641/ijerph-03-00185f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/9d8d2c3e77bc/ijerph-03-00185f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/878fd5aac2e9/ijerph-03-00185f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/8161f91c9a95/ijerph-03-00185f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/bb3e371fdf9e/ijerph-03-00185f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/b891b496af6e/ijerph-03-00185f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/d11c4c4e218b/ijerph-03-00185f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/0a191067b641/ijerph-03-00185f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/9d8d2c3e77bc/ijerph-03-00185f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/878fd5aac2e9/ijerph-03-00185f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/8161f91c9a95/ijerph-03-00185f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/bb3e371fdf9e/ijerph-03-00185f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/b891b496af6e/ijerph-03-00185f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/d11c4c4e218b/ijerph-03-00185f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7733/3807509/0a191067b641/ijerph-03-00185f7.jpg

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