Spataro Pasquale, Di Pietro Angela, Scoglio Maria Elena, Visalli Giuseppa, Chirico Cristina, Picerno Isa, Ferlazzo Nadia, Campo Salvatore, Bellinghieri Guido, Savica Vincenzo, Santoro Domenico, Buemi Michele, Costantino Franco
Department of Hygiene, Preventive Medicine, and Public Health, University of Messina, Italy.
Ren Fail. 2006;28(5):441-8. doi: 10.1080/08860220600684225.
Recently, the identification of the SEN virus as a possible etiological agent of parental transmission hepatitis led to the study of the prevalence of such pathogen agents, particularly SENV-H, in our population. This paper compares the rate prevalence in high-risk subjects, such as dialysis patients, and low-risk subjects, such as blood donors.
The study was carried out on SEN virus DNA extracted from serum of dialysis patients and blood donors, and the presence of viral genomes was performed by the nested PCR method.
The results showed a higher prevalence in male blood donors, supporting the hypothesis of an epidemiological role for sexual and also parental transmission, as is clearly demonstrated by the high prevalence in dialysis patients. The result reduced the importance of the possible etiological role of the SEN virus due to the high percentage of positivity in healthy population, and it induces one to consider poorly significant the pathogenicity of such viral agents.
For this instance, the authors, in agreement with the phylogenically related TT virus, described SEN viruses as absolutely not pathogens and considered them as "simple guests."
最近，SEN病毒被鉴定为可能导致母婴传播性肝炎的病原体，这引发了对这类病原体，尤其是SENV-H在我们人群中流行率的研究。本文比较了高危人群（如透析患者）和低危人群（如献血者）中的感染率。
本研究对从透析患者和献血者血清中提取的SEN病毒DNA进行检测，采用巢式PCR法检测病毒基因组的存在情况。
结果显示男性献血者中的感染率较高，这支持了性传播以及母婴传播在流行病学中起作用的假设，透析患者中的高感染率清楚地证明了这一点。由于健康人群中的阳性率较高，该结果降低了SEN病毒可能的病因学作用的重要性，并促使人们认为这类病毒病原体的致病性不太显著。
在这种情况下，作者与系统发育相关的TT病毒一致，将SEN病毒描述为绝对无致病性，并将它们视为“单纯的过客”。
