Blair P B, Lane M A
J Immunol. 1975 Jul;115(1):184-9.
Both T cell-mediated killing and non-T cell-mediated killing of target MTV-induced mammary tumor cells can be detected in microcytotoxicity assay tests of spleen cells from mice immunologically responsive to either the histocompatibility antigens or the virus-associated antigens of the target cells. The non-T cell-mediated cytotoxicity is antibody-dependent; otherwise inactive cells (null cells) can be recruited to activity by target cell-specific factors obtained from the supernatant of short-term cultures of sensitized B cells or provided by the introduction of a small number of sensitized B cells to the wells of the assay plate.
在对靶细胞的组织相容性抗原或病毒相关抗原产生免疫应答的小鼠脾脏细胞的微量细胞毒性试验中，可检测到T细胞介导的对MTV诱导的乳腺肿瘤靶细胞的杀伤作用以及非T细胞介导的杀伤作用。非T细胞介导的细胞毒性是抗体依赖性的；否则，无活性细胞（裸细胞）可通过从致敏B细胞短期培养上清液中获得的靶细胞特异性因子或通过向试验板孔中引入少量致敏B细胞而被激活发挥活性。
