Blair P B, Lane M A, Yagi M J
J Immunol. 1975 Jul;115(1):190-4.
Spleen cells from BALB/c females exposed to or neonatally infected with mammary tumor virus (MTV) are cytotoxic to MTV-induced mammary tumor cells in microcytotoxocity assay. This activity can be partially or completely blocked by pretreatment of spleen cells with MTV purified from milk. Murine leukemia virus (MuLV) has no effect. T cell responses of virgin and multiparous BALB/cfC3H females are effectively blocked. Non-T cell responses of multiparous BALB/cfC3H females or of virgin BALB/c females are blocked by some but not all of the MTV antigen preparations. MuLV, but not MTV, can block activity of spleen cells from MuLV-sensitized donors against target MuLV-producing tumor cells.
在微量细胞毒性试验中，暴露于乳腺肿瘤病毒（MTV）或在新生期感染MTV的BALB/c雌性小鼠的脾细胞，对MTV诱导的乳腺肿瘤细胞具有细胞毒性。用从乳汁中纯化的MTV对脾细胞进行预处理，可部分或完全阻断这种活性。小鼠白血病病毒（MuLV）则无此作用。未生育和经产的BALB/cfC3H雌性小鼠的T细胞反应可被有效阻断。经产的BALB/cfC3H雌性小鼠或未生育的BALB/c雌性小鼠的非T细胞反应，可被部分而非全部的MTV抗原制剂阻断。MuLV而非MTV，可阻断来自对MuLV致敏的供体的脾细胞对产生MuLV的靶肿瘤细胞的活性。
