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[阻塞性睡眠呼吸暂停的多级手术。初步客观结果]

[Multi-level surgery for obstructive sleep apnea. Preliminary objective results].

作者信息

Verse T, Baisch A, Hörmann K

机构信息

Universitäts-HNO-Klinik, Mannheim.

出版信息

Laryngorhinootologie. 2004 Aug;83(8):516-22. doi: 10.1055/s-2004-814553.

Abstract

BACKGROUND

Nasal continuous positive airway pressure (nCPAP) ventilation is the gold standard in the treatment of obstructive sleep apnea (OSA). Unfortunately nCPAP does not exceed long-term compliance rates of much more than 60 percent. Therefore, surgical strategies are of growing interest in this field. Today, so called multi-level surgeries are favored which combine at least one surgical procedure on both the velopharyngeal and the retrolingual section of the upper airway. The Mannheim concept combines at least one surgical procedure to the soft palate (UPPP or Uvulaflap) inclusive tonsillectomy and a hyoid suspension and/or a radiofrequency procedure on the base of tongue.

METHODS

In between July 2000 and February 2003, 139 patients with OSA were included in the protocol. By now 46 patients finished the follow-up. Mean age was 51.9 years, the mean body mass index was 28.5 kg m (- 2). All patients underwent as well preoperatively as postoperatively a fully attended polysomnography in the sleep lab using standard criteria. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS).

RESULTS

Before surgery the mean apnea-hypopnea-index (AHI) was 36.5 +/- 22.2, the mean ESS score was 10.4. Postoperatively the mean AHI decreased to 24.9 +/- 21.6 (p < 0.01) and the mean ESS score to 7.1 (p < 0.05). After surgery 39.1 % of the subjects were regarded as cured (reduction of AHI > or = 50 % and below 15). Another 30.4 % were substantially improved (reduction of AHI > 20 %). Altogether 69.6 % of the patients were counted as responders. Cure rates decreased with increasing AHI and BMI. The hyoid suspension showed a positive effect on the treatment success.

CONCLUSIONS

The presented concept shows inferior success rates than other more invasive concepts. This might be due to the abandonment of the mandibular osteotomy with genioglossus advancement.

摘要

背景

经鼻持续气道正压通气(nCPAP)是治疗阻塞性睡眠呼吸暂停(OSA)的金标准。遗憾的是,nCPAP的长期依从率不超过60%多。因此,手术策略在该领域越来越受到关注。如今,所谓的多级手术受到青睐,这种手术在上气道的腭咽和舌后段至少联合进行一种手术。曼海姆概念包括至少一种针对软腭的手术(悬雍垂腭咽成形术或悬雍垂瓣术)并切除扁桃体,以及在舌根处进行舌骨悬吊和/或射频手术。

方法

在2000年7月至2003年2月期间,139例OSA患者被纳入该方案。到目前为止,46例患者完成了随访。平均年龄为51.9岁,平均体重指数为28.5 kg/m²。所有患者在术前和术后均在睡眠实验室按照标准标准进行了全程多导睡眠监测。使用爱泼华嗜睡量表(ESS)评估日间嗜睡情况。

结果

手术前平均呼吸暂停低通气指数(AHI)为36.5±22.2,平均ESS评分为10.4。术后平均AHI降至24.9±21.6(p<0.01),平均ESS评分降至7.1(p<0.05)。手术后39.1%的受试者被视为治愈(AHI降低≥50%且低于15)。另外30.4%有显著改善(AHI降低>20%)。总共69.6%的患者被视为有反应者。治愈率随着AHI和体重指数的增加而降低。舌骨悬吊对治疗成功有积极作用。

结论

所呈现的概念显示出比其他更具侵入性的概念更低的成功率。这可能是由于放弃了下颌骨截骨术联合颏舌肌前移术。

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