Woodson B Tucker, Robinson Sam, Lim Hyun J
Department of Otolaryngology and Communications Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Otolaryngol Head Neck Surg. 2005 Aug;133(2):211-7. doi: 10.1016/j.otohns.2005.03.061.
Uvulopalatopharyngoplasty (UPPP) success rates in patients classified with Friedman stage 3 is reported as 8%. Surgical failure may result from persistent obstruction at the palate, which may be addressed by pharyngoplasty with palatal advancement (PA). The effectiveness of PA versus UPPP was evaluated by using polysomnographic outcomes in a retrospective cohort of patients classified with Friedman stage 3.
Surgical records were reviewed for PA (n = 47) and UPPP (n = 124). Clinical records were reviewed and reclassified by Friedman stage. Respiratory data were collected from overnight polysomnography. Statistical analysis was conducted of continuous variables (ANOVA), categorical variables (chi2), and adjusted odds ratios by using logistic regression.
PA (n = 30) and UPPP (n = 44) did not differ in baseline apnea hypopnea index (AHI), age, or BMI. Both PA (48.3 +/- 24.6 to 19.8 +/- 16.8 events per hour, P < 0.000) and UPPP (47.9 +/- 30.0 to 30.9 +/- 24.2 events per hour, P < 0.000) improved with surgery. In the PA group, final AHI was lower (17.1 +/- 30.1 versus 28.5 +/- 25.6, P < 0.04) and postoperative change was greater (30.9 +/- 24.2 versus 19.8 +/- 16.8, P < 0.02). For patients with Friedman stage 3, odds ratio of having an AHI of <20 events per hour and a greater than 50% reduction with PA compared with UPPP was 3.80 (95% CI, 1.41-10.29, P < 0.013). Adjusted for age, body mass index, preoperative apnea severity, and tongue-base surgery, OR was 5.77 (95% CI of 1.80-17.98).
Polysomnographic outcomes using AHI support the use of palatopharyngoplasty using palatal advancement as an effective treatment of obstructive sleep apnea. PA may offer benefit over UPPP alone in patients classified with Friedman stage 3.
据报道,弗里德曼3期患者悬雍垂腭咽成形术(UPPP)的成功率为8%。手术失败可能是由于腭部持续阻塞所致,可通过腭前徙咽成形术(PA)来解决。通过对弗里德曼3期患者的回顾性队列进行多导睡眠图结果评估,比较PA与UPPP的有效性。
回顾PA组(n = 47)和UPPP组(n = 124)的手术记录。对临床记录进行回顾,并根据弗里德曼分期重新分类。从夜间多导睡眠图收集呼吸数据。对连续变量进行方差分析(ANOVA),对分类变量进行卡方检验,并使用逻辑回归分析调整后的优势比。
PA组(n = 30)和UPPP组(n = 44)在基线呼吸暂停低通气指数(AHI)、年龄或体重指数方面无差异。PA组(每小时事件数从48.3±24.6降至19.8±16.8,P < 0.000)和UPPP组(每小时事件数从47.9±30.0降至30.9±24.2,P < 0.000)术后均有改善。PA组最终AHI较低(17.1±30.1对28.5±25.6;P < 0.04),术后变化更大(30.9±24.2对19.8±16.8;P < 0.02)。对于弗里德曼3期患者,与UPPP相比,PA术后AHI<20次/小时且降低幅度大于50%的优势比为3.80(95%CI,1.41 - 10.29;P < 0.013)。校正年龄、体重指数、术前呼吸暂停严重程度和舌根手术后,优势比为5.77(95%CI为1.80 - 17.98)。
使用AHI的多导睡眠图结果支持将腭前徙咽成形术作为治疗阻塞性睡眠呼吸暂停综合征的有效方法。对于弗里德曼3期患者,PA可能比单纯UPPP更具优势。