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比较两种舌根手术治疗中度至重度阻塞性睡眠呼吸暂停综合征的随机研究。

Randomized study comparing two tongue base surgeries for moderate to severe obstructive sleep apnea syndrome.

作者信息

Fernández-Julián Enrique, Muñoz Noelia, Achiques Maria Teresa, García-Pérez Miguel A, Orts Miguel, Marco Jaime

机构信息

Otorhinolaryngology Department, Hospital Clínico Universitario, University of Valencia, Valencia, Spain.

出版信息

Otolaryngol Head Neck Surg. 2009 Jun;140(6):917-23. doi: 10.1016/j.otohns.2009.02.010. Epub 2009 Apr 15.

Abstract

OBJECTIVE

To compare the effectiveness and morbidity of the tongue base radiofrequency and tongue base suspension techniques combined with uvulopalatopharyngoplasty for moderate to severe obstructive sleep apnea.

STUDY DESIGN AND SETTING

Prospective and randomized surgical trial at a university hospital.

METHODS

In total, 57 patients received either tongue base radiofrequency reduction (n = 29) or tongue base suspension (n = 28). Apnea-hypopnea index, lowest oxygen saturation (polysomnography), Epworth score, and side effects were assessed. Success was defined as a > or =50 percent reduction and final apneahypopnea index < 15/h, and an Epworth score < 11.

RESULTS

The success rates of the two procedures were 57.1 percent and 51.7 percent, respectively (P = 0.79), but only 12.5 percent and 10 percent, respectively (P = 0.87), in obese patients. Body mass index (P = 0.0002) was the main predictor of success in a logistic regression analysis. Tongue base suspension demonstrated higher morbidity (P < 0.05).

CONCLUSIONS

The effectiveness of tongue base suspension was similar to that of tongue base radiofrequency reduction, although with significantly higher morbidity, for moderate to severe obstructive sleep apnea. The effectiveness of both techniques was lower in obese patients.

SIGNIFICANCE

Neither technique should be used in obese patients who have moderate to severe obstructive sleep apnea.

摘要

目的

比较舌根射频消融术和舌根悬吊术联合悬雍垂腭咽成形术治疗中重度阻塞性睡眠呼吸暂停的有效性和并发症发生率。

研究设计与地点

在一所大学医院进行的前瞻性随机外科试验。

方法

总共57例患者分别接受舌根射频消融术(n = 29)或舌根悬吊术(n = 28)。评估呼吸暂停低通气指数、最低血氧饱和度(多导睡眠图)、爱泼华嗜睡量表评分及副作用。成功定义为呼吸暂停低通气指数降低≥50%且最终呼吸暂停低通气指数<15次/小时,以及爱泼华嗜睡量表评分<11分。

结果

两种手术的成功率分别为57.1%和51.7%(P = 0.79),但肥胖患者的成功率分别仅为12.5%和10%(P = 0.87)。在逻辑回归分析中,体重指数(P = 0.0002)是成功的主要预测因素。舌根悬吊术的并发症发生率更高(P < 0.05)。

结论

对于中重度阻塞性睡眠呼吸暂停,舌根悬吊术的有效性与舌根射频消融术相似,尽管并发症发生率显著更高。两种技术在肥胖患者中的有效性均较低。

意义

对于患有中重度阻塞性睡眠呼吸暂停的肥胖患者,这两种技术均不应使用。

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