Turba Maria Elena, Forni Monica, Gandini Gualtiero, Gentilini Fabio
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, via Tolara di sopra 50, 40064, Ozzano Emilia, Bologna, Italy.
J Neurooncol. 2007 Jan;81(2):123-9. doi: 10.1007/s11060-006-9213-2. Epub 2006 Jul 7.
Matrix metalloproteinases (MMP) 2 and 9 are enzymes known to degrade several protein components of the extracellular matrix. In humans, increased concentrations of these enzymes have been demonstrated in the cerebrospinal fluid (CSF) of subjects affected by many neurological conditions including brain tumours; nevertheless comparative data in dogs are completely lacking. Aim of this study was to investigate these molecules in CSF of dogs diagnosed with CNS neurological diseases. Higher activity of MMP 2 and 9 was revealed in dogs with space occupying lesions of likely neoplastic origin in comparison to dogs with idiopathic epilepsy. Statistical modelling reveals that increased MMP 9 activity is mainly due to leukocytes recruitment and local synthesis.
基质金属蛋白酶（MMP）2和9是已知可降解细胞外基质多种蛋白质成分的酶。在人类中，包括脑肿瘤在内的许多神经疾病患者的脑脊液（CSF）中已证实这些酶的浓度会升高；然而，犬类的相关比较数据却完全缺失。本研究的目的是调查被诊断患有中枢神经系统（CNS）神经疾病的犬类脑脊液中的这些分子。与特发性癫痫犬相比，具有可能肿瘤起源的占位性病变的犬类中MMP 2和9的活性更高。统计模型显示，MMP 9活性增加主要归因于白细胞募集和局部合成。
