Suon Sokreine, Yang Ming, Iacovitti Lorraine
Department of Molecular Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Farber Institute for Neurosciences, Department of Neurology, Thomas Jefferson University, 900 Walnut Street, JHN 462, Philadelphia, PA 19107, USA.
Farber Institute for Neurosciences, Department of Neurology, Thomas Jefferson University, 900 Walnut Street, JHN 462, Philadelphia, PA 19107, USA.
Brain Res. 2006 Aug 23;1106(1):46-51. doi: 10.1016/j.brainres.2006.05.109. Epub 2006 Jul 10.
Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neurons appeared to survive transplantation, there were abundant GABA neurons present in the graft. By 4 weeks, however, all cells had died. Finding ways to prolong survival and promote the appropriate neurotransmitter phenotype is essential if hMSCs are to be clinically useful.
悬浮培养的成人骨髓基质细胞（hMSCs）产生了神经祖细胞（NP）球，这些细胞能够表达多巴胺能（DA）和γ-氨基丁酸能（GABA）特性。移植到帕金森病大鼠体内后，2周时出现了人NP细胞和神经元。虽然似乎没有DA神经元在移植后存活，但移植物中存在大量GABA神经元。然而，到4周时，所有细胞都死亡了。如果hMSCs要在临床上发挥作用，找到延长存活时间并促进适当神经递质表型的方法至关重要。
