从新西兰尖刺菱形藻中分离和鉴定pectenotoxins-13和-14
Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand.
作者信息
Miles Christopher Owen, Wilkins Alistair L, Hawkes Allan D, Jensen Dwayne J, Selwood Andrew I, Beuzenberg Veronica, Mackenzie A Lincoln, Cooney Janine M, Holland Patrick T
机构信息
AgResearch Ltd., Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand.
出版信息
Toxicon. 2006 Aug;48(2):152-9. doi: 10.1016/j.toxicon.2006.04.005. Epub 2006 May 9.
Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141-150]. PTX-13 underwent slow deuteration at the 13beta-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.
从新西兰南岛西海岸采集的尖刺菱形藻提取物中分离出两种新型的pectenotoxins（PTXs），即PTX - 13和 - 14。通过核磁共振光谱和液相色谱 - 质谱研究，这些化合物被鉴定为PTX - 2的氧化类似物。PTX - 13（32R - 羟基PTX - 2）与[Suzuki等人，2003年。pectenotoxins的螺环缩酮立体异构体的液相色谱 - 质谱分析以及来自新西兰的有毒甲藻尖刺菱形藻中新型pectenotoxin异构体的分析。《色谱杂志A》992，141 - 150]报道的未鉴定类似物PTX - 11x相对应。在核磁共振分析过程中，PTX - 13在13β位发生缓慢的氘代反应。PTX - 14对应于PTX - 13的32,36 - 脱水产物，可能是一种假象。
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