Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Alexandra Nevskogo 14, Russia.
Kemerovo State University, 650000 Krasnaya, Kemerovo, Russia.
Molecules. 2019 Nov 17;24(22):4165. doi: 10.3390/molecules24224165.
Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes.
螺环母核是药物发现中新兴的优势结构。它们在天然产物领域也无处不在。然而，直到今天，还没有人试图分析天然产物中各种螺环母核的结构多样性及其在文献中报道的独特化合物的相对丰度。本文旨在填补这一空白，分析含有各种大小螺环结构的结构独特的天然产物的多样性。
