D'Onofrio F, Miele L, Diaco M, Santoro L, De Socio G, Montalto M, Grieco A, Gasbarrini G, Manna R
Department of Internal Medicine, Catholic University, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy.
Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):445-8. doi: 10.1177/039463200601900222.
In the last few years many studies have shown the potential role of different triggers in the pathogenesis of several autoimmune diseases. In particular, in Sjogren's syndrome the presence of a genetic background is considered determining, but environmental factors have recently been described as triggers or precipitators. In this report, we describe the case of a young woman affected by celiac disease in which an Ascaris lumbricoides infestation and estrogen therapy could have played a role in the development of Sjogren's syndrome.
在过去几年中,许多研究表明不同触发因素在几种自身免疫性疾病的发病机制中具有潜在作用。特别是在干燥综合征中,遗传背景的存在被认为是决定性的,但最近环境因素被描述为触发因素或促发因素。在本报告中,我们描述了一名患有乳糜泻的年轻女性病例,其中蛔虫感染和雌激素治疗可能在干燥综合征的发展中起了作用。