利用高变RFLP标记诊断双胎合子性
Diagnosis of twin zygosity by hypervariable RFLP markers.
作者信息
Akane A, Matsubara K, Shiono H, Yamada M, Nakagome Y
机构信息
Department of Legal Medicine, Shimane Medical University, Izumo, Japan.
出版信息
Am J Med Genet. 1991 Oct 1;41(1):96-8. doi: 10.1002/ajmg.1320410123.
The application of variable number of tandem repeat (VNTR) markers to the determination of twin zygosity was investigated. In the first case, which was performed with the use of six VNTR markers, the probability of monozygosity, calculated from Essen-Möller's formula II, was 0.99972. In the other three cases in which four VNTR markers were analyzed, the probabilities were 0.98251-0.99557. These results suggest that VNTR markers are useful for determination of twin zygosity.
研究了可变数目串联重复（VNTR）标记在双合子性别的判定中的应用。在第一个案例中，使用了六个VNTR标记，根据埃森-默勒公式II计算出的同卵双生概率为0.99972。在另外三个分析了四个VNTR标记的案例中，概率为0.98251-0.99557。这些结果表明VNTR标记对于双合子性别的判定是有用的。
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