饥饿诱导的大鼠肝功能定量指标变化。

Starvation induced changes in quantitative measures of liver function in the rat.

作者信息

Hansen B A, Poulsen H E

机构信息

Department of Medicine A, Division of Hepatology and Laboratories of Experimental Pathology, Rigshopitalet A 2152, DK-2100 Copenhagen, Denmark.

出版信息

Clin Nutr. 1986 Nov;5(4):213-6. doi: 10.1016/0261-5614(86)90028-2.

DOI:10.1016/0261-5614(86)90028-2

PMID:16831773

Abstract

Liver function was estimated quantitatively as the capacity of urea-N synthesis (CUNS), the galactose elimination capacity (GEC) and the antipyrine plasma clearance (APC) in rats following 24, 48, and 96 h of food deprivation. CUNS rose to a maximum following 24 h of starvation, then decreased to the control value at 48, 72, and 96 h (p = 0.02). GEC decreased following starvation, significant so at 48 h (p = 0.02). APC decreased at 48, and 72 h (p = 0.01), but rose to the control value at 96 h. It is concluded that a precise standardisation of starvation is important for interpretation of minor changes in CUNS, GEC, and APC.

摘要

在大鼠禁食24、48和96小时后，通过尿素氮合成能力（CUNS）、半乳糖清除能力（GEC）和安替比林血浆清除率（APC）对肝功能进行定量评估。CUNS在饥饿24小时后升至最高，然后在48、72和96小时降至对照值（p = 0.02）。饥饿后GEC降低，在48小时时显著降低（p = 0.02）。APC在48和72小时降低（p = 0.01），但在96小时升至对照值。结论是，饥饿的精确标准化对于解释CUNS、GEC和APC的微小变化很重要。