大鼠四氯化碳诱导的肝硬化：不可逆的组织学变化和不同程度的功能损害。

CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.

作者信息

Fischer-Nielsen A, Poulsen H E, Hansen B A, Hage E, Keiding S

机构信息

Department of Medicine A, Rigshospitalet, Copenhagen, Denmark.

出版信息

J Hepatol. 1991 Jan;12(1):110-7. doi: 10.1016/0168-8278(91)90919-3.

DOI:10.1016/0168-8278(91)90919-3

PMID:2007767

Abstract

Cirrhosis of the rat liver was induced by a 12 week individualized CCl4/phenobarbital treatment. After treatment, all surviving animals (81%) showed cirrhosis of the liver. The cirrhosis induced was irreversible when evaluated 24 weeks after cessation of treatment. Quantitative liver function measurements were reduced in a differentiated manner. Ranked according to the most pronounced changes they are: capacity of urea-N synthesis (CUNS), galactose elimination capacity (GEC) and antipyrine clearance (APC). Hepatic glutathione concentrations were only slightly decreased after the CCl4 treatment. It is possible to produce a high incidence of irreversible cirrhosis with differentiated functional impairment in the rat.

摘要

通过为期12周的个体化四氯化碳/苯巴比妥治疗诱导大鼠肝硬化。治疗后，所有存活的动物（81%）均出现肝硬化。在治疗停止24周后评估，所诱导的肝硬化是不可逆的。定量肝功能测量结果呈差异化降低。按照变化最显著程度排序依次为：尿素氮合成能力（CUNS）、半乳糖清除能力（GEC）和安替比林清除率（APC）。四氯化碳治疗后肝脏谷胱甘肽浓度仅略有下降。在大鼠中有可能产生高发生率的伴有差异化功能损害的不可逆肝硬化。