Mamchur V I
Anesteziol Reanimatol. 1991 Jul-Aug(4):43-6.
In experiments on rats the involvement of neuromediator systems into the development of outer manifestations of general anesthesia with ketamine and thiopental sodium was determined by the ability of neuromediator analyzers to change significantly their absolute values. The role of neuromediator mechanisms in general ketamine anesthesia can be determined by opiate-, serotonin-, GABA- and alpha 2-adrenomimetic, as well as alpha 1 and beta-adrenoblocking, anti-dopamine and anticholinergic properties of the anesthetic. The role of neuromediator systems in general anesthesia with thiopental sodium is determined by GABA-mimetic, antiadrenergic (alpha 2-agonist and alpha 1- and beta-adrenoceptor antagonist), anticholinergic and antidopaminergic properties of the thiobarbiturate.
在对大鼠的实验中，通过神经介质分析仪显著改变其绝对值的能力，确定了神经介质系统参与氯胺酮和硫喷妥钠全身麻醉外在表现的发展过程。麻醉剂的阿片样物质、血清素、GABA和α2 - 肾上腺素能模拟特性，以及α1和β - 肾上腺素能阻断、抗多巴胺和抗胆碱能特性，可确定神经介质机制在氯胺酮全身麻醉中的作用。硫代巴比妥酸盐的GABA模拟、抗肾上腺素能（α2 - 激动剂以及α1和β - 肾上腺素能受体拮抗剂）、抗胆碱能和抗多巴胺能特性，确定了神经介质系统在硫喷妥钠全身麻醉中的作用。
