Mamchur V I
Farmakol Toksikol. 1987 Jan-Feb;50(1):21-4.
Under conditions of free behaviour of rabbits with electrodes implanted into the brain structures it was found that ketamine and sodium thiopental decrease the excitability in the dorsal hippocamp, reticular formation and periaqueductal gray matter of the midbrain. Excitability of the frontal neocortex increases during general anesthesia with ketamine and decreases during thiopental narcosis. Changes in excitability of the studied cerebral structures during general anesthesia can be determined by common N-cholinoblocking and alpha-adrenomimetic properties of ketamine and thiopental at the level of the dorsal hippocamp, cholinoblocking and adrenoblocking properties at the level of the reticular formation and central gray matter. In the frontal cortex ketamine presented properties of an M-cholinomimetic and adrenomimetic agent, sodium thiopental--those of a M-cholinoblocker and beta-adrenoblocker.
在将电极植入兔脑结构的自由行为条件下，发现氯胺酮和硫喷妥钠可降低中脑背侧海马、网状结构和导水管周围灰质的兴奋性。在氯胺酮全身麻醉期间额叶新皮质的兴奋性增加，而在硫喷妥钠麻醉期间则降低。全身麻醉期间所研究脑结构兴奋性的变化可由氯胺酮和硫喷妥钠在背侧海马水平的共同N-胆碱阻断和α-肾上腺素能模拟特性、在网状结构和中央灰质水平的胆碱阻断和肾上腺素阻断特性来确定。在额叶皮质，氯胺酮表现出M-胆碱能模拟剂和肾上腺素能模拟剂的特性，硫喷妥钠则表现出M-胆碱阻断剂和β-肾上腺素能阻断剂的特性。
