单眼剥夺的人类初级视觉皮层中的细胞色素氧化酶和神经丝反应性
Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex.
作者信息
Duffy Kevin R, Murphy Kathryn M, Frosch Matthew P, Livingstone Margaret S
机构信息
Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
出版信息
Cereb Cortex. 2007 Jun;17(6):1283-91. doi: 10.1093/cercor/bhl038. Epub 2006 Jul 10.
Abstract
Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.
摘要
先前对人类初级视觉皮层（V1）的研究表明，单眼摘除后，细胞色素氧化酶（CO）染色存在明显的眼特异性降低。我们通过检查一名长期单眼失明患者V1中的CO染色和神经丝标记，扩展了这些结果。发现神经丝反应性降低的模式与淡染的CO染色眼优势柱对齐。与非剥夺柱中的神经元相比，位于剥夺眼优势柱内的神经元明显更小。对CO斑和眼优势柱之间关系的空间分析表明，剥夺和非剥夺斑都倾向于与眼优势柱的中心对齐。
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