Lim Hyun, Son Kun Ho, Chang Hyeun Wook, Kang Sam Sik, Kim Hyun Pyo
College of Pharmacy, Kangwon National University, Chunchon, Korea.
Arch Pharm Res. 2006 Jun;29(6):503-7. doi: 10.1007/BF02969424.
Flavonoids are known as natural anti-inflammatory agents. In this investigation, an anti-inflammatory potential of new topical preparation (SK Ato Formula) containing flavonoid mixtures from Scutellaria baicalensis Georgi roots and Ginkgo biloba L. leaves with an extract of Gentiana scabra Bunge roots was evaluated in an animal model of chronic skin inflammation. Multiple 12-O-tetradecanoylphorbol-13-acetate treatments for 7 consecutive days on ICR mouse ear provoked a chronic type of skin inflammation: dermal edema, epidermal hyperplasia and infiltration of inflammatory cells. When topically applied in this model, this new formulation (5-20 microL/ear/treatment) reduced these responses. Furthermore, it inhibited prostaglandin E2 generation (17.1-33.3%) and suppressed the expression of proinflammatory genes, cyclooxygenase-2 and interleulin-1beta in the skin lesion. Although the potency of inhibition was lower than that of prednisolone, all these results suggest that Ato Formula may be beneficial for treating chronic skin inflammatory disorders such as atopic dermatitis.
黄酮类化合物被认为是天然抗炎剂。在本研究中，在慢性皮肤炎症动物模型中评估了一种新的局部制剂（SK Ato配方）的抗炎潜力，该制剂含有黄芩根和银杏叶中的黄酮类混合物以及龙胆根提取物。对ICR小鼠耳部连续7天多次给予12-O-十四烷酰佛波醇-13-乙酸酯诱发了慢性皮肤炎症：皮肤水肿、表皮增生和炎症细胞浸润。当在该模型中局部应用时，这种新制剂（5-20微升/耳/次治疗）减轻了这些反应。此外，它抑制了前列腺素E2的生成（17.1-33.3%），并抑制了皮肤病变中促炎基因环氧合酶-2和白细胞介素-1β的表达。尽管抑制效力低于泼尼松龙，但所有这些结果表明Ato配方可能对治疗慢性皮肤炎症性疾病如特应性皮炎有益。
